Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...

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Get Permission Aliyeva and Rustambayova: Choroidal neovascularization caused by angioid streaks: seven-year follow-up


Introduction

Angioid streaks are red-brown or red-grey irregular lines of variable size and shape radiating from the peripapillary region for varying distances into the fundus, lying under the retinal vessels.1 They are caused by ruptures of calcified Bruch’s membrane and are later often altered in appearance by proliferative changes along or within them.2

The most common and sight threating complication of angioid streaks is choroidal neovascularization (CNV), which is often bilateral but asymmetric.3 This complication becomes challenging for ophthalmologists and deteriorates the prognosis of disease when it affects the macular region.4

In the therapy of CNV caused by angioid streaks, intravitreal anti vascular endothelial growth factor (VEGF) drugs are currently the treatment of choice, and they have been proven to improve or stabilize visual acuity.3, 5, 6

In this case intravitreal injection of bevacizumab and aflibercept was used as the treatment of choice.

Case Presentation

A 29-year-old man presented in 2014 with complaints of impaired vision in his left eye. The best corrected visual acuity (BCVA) was 20/32 in his right eye and 20/2000 in his left eye. Intraocular pressure measurements and the slit lamp biomicroscopic examination of anterior segments in both eyes were found to be normal. Dilated fundus examination revealed bilateral subretinal red-brown lines extending from peripapillary area to periphery of fundus and macula. There were chorioretinal lesions with surrounding subretinal fluid in the superior nasal part of macula in both eyes. This lesion defined as choroidal neovascular membrane (CNVM) extended to parafovea and fovea in his left eye. Some intraretinal hemorrhages at the inferior border of the subretinal fluid area were also seen in the left eye. Optical coherence tomography (OCT) examinations of the macula and the lesion (Figure 1) showed high reflective choroidal neovascular membrane and subretinal fluid in both eyes. Central macular thickness was 253 µm in the right eye and 822 µm in the left eye. The fundus fluorescein angiography (FFA) examination demonstrated an early macular hyperfluorescent lesion with late staining and hyperfluorescent linear streaks that expanded from the peripapillary region to the periphery in both eyes. The mottled hyperfluorescence was seen in early phase of angiogram (Figure 1). The examinations confirmed the final diagnosis as angioid streaks with the complication of choroidal neovascularization. Intravitreal bevacizumab therapy was initiated with three consecutive injections in the right eye and two consecutive injections in the left eye at one-month intervals.

Figure 1

Subretinal lesion is seen on superior nasal area in the fundus photos of both eyes (A and D). Early phase shows (B and E) increased filling of the CNVM. Irregular hyperfluorescent bands are note dradiating away from the optic disc. The mottled hyperfluorescence is better seen. Late phase of the angiogram shows leakage of the dye from the CNVM (C and F). CNVM with subretinal fluid is seen in OCT images of lesions in both eyes (G and H)

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After injections the BCVA increased to 20/25 in the right eye, 20/800 in the left eye. After first injections patient was admitted to the FFA examination again. There was not any active leakage from hyperfluorescent lesion in the right eye, whereas the FFA showed leakage of dye from the CNVM in the left eye (Figure 2). Intravitreal bevacizumab injection was performed in the left eye. After 3 total intravitreal injections of bevacizumab, therapy was discontinued in the left eye due to macular scar formation, no active process and stable BCVA (it was 20/2000 after third injection).

Figure 2

After injections of bevacizumab there is no leakage from the CNVM in the right eye (B and C). In the left eye small leakage is seen from the CNVM in the left eye (E and F). The mottled hyperfluorescence is better seen in early phase angiogram

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Repetitive intravitreal bevacizumab injections were continued in his right eye and were performed due to membrane activity, monitored by OCT images (Figure 3). It should be noted that during the covid-19 pandemic, the patient did not visit the clinic for 10 months. This led to the progression of the subretinal membrane and a significant decrease in visual acuity in the right eye. After a follow-up period of 7 years, the patient received 22 intravitreal bevacizumab and 4 intravitreal aflibercept injections in the right eye and 3 intravitreal bevacizumab injections in the left eye. No injection-related adverse events were reported. At last visit the BCVA was 20/400 in his right eye and 20/2000 in the left eye.

Figure 3

A) OCT image of the macula in the right eye at first visit. Subretinal fluid is observed (arrow). B) At 20 months of follow-up, the patient received a total of 7 injections. The lesion demonstrates fibrous scar (arrow head), intraretinal cysts over the fibrous scar (asterisks), subretinal fluid (arrows). C) At 28 months of follow-up after receiving another 2 injections, arrowhead indicates fibrous scar with no subretinal fluid activity. D) At 4 years of follow-up, after receiving another 11 injections, arrowhead shows fibrous scar extending subfoveally. E) After 7 years of follow-up, the patient received a total of 26 injections, OCT image demonstrates subfoveal fibrous scar. F) Fundus image of right eye after 7 years. There is a large fibrous scar over macular region. Prominent pigment hypertrophy is seen within the scar

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Discussion

Angioid streaks are dark reddish-brown irregular lines radiating from the optic disc toward the retinal periphery. They are often bilateral and indicate crack-like breaks of a calcified and fragile Bruch membrane.3

In up to 50% cases, angioid streaks can be idiopathic.7 Angioid streaks are associated with systemic conditions in more than 50 percent of patients. Pseudoxanthoma elasticum, Paget disease, Ehlers–Danlos syndrome, Marfan syndrome, hemoglobinopathies, and hypercalcemia are common systemic associations.3 In this patient, we thought of pseudoxanthoma elasticum (PXE) due to specific changes in the neck area and mottled fundus or peau d’orange appearance (mottled hyperfluorescence in angiogram) (Figure 1, Figure 2). The mottled fundus, also known as "peau d'orange," is the pathognomonic feature of PXE in the fundoscopic examination.1

Angioid streaks cause some complications. They include subretinal bleed caused by choroidal rupture after little trauma, choroidal neovascularization, foveal atrophy, or thinning.7 The most common and significant complication of angioid streaks is choroidal neovascularization, and it occurs mainly bilaterally and asymmetrically.3 It is shown that 70-86% of patients with angioid streaks develop CNVM.8 If left untreated, it can lead to severe vision loss in middle-aged working adults.3

The patient was diagnosed with type II CNV by OCT imaging as the neovascular vessels were enlarging in the subretinal space between the retinal pigment epithelium and the neurosensory retina, as opposed to type I CNV, in which the vessels grow below the retinal pigment epithelium.9, 10 The most prominent form is type II CNV, whereas type I and mixed (type I and type II) forms can occur in up to 16 percent of eyes.11

Anti-VEGF is the treatment of choice in therapy of CNV caused by angioid streaks, as these agents have been shown to improve or stabilize the visual acuity.3, 5, 6 Battaglia et al. reported a 33% increase and 46.6% stabilization in visual acuity, with the mean number of injections 2.5.12 Alagoz C. et al. demonstrated an improvement or stabilization in visual acuity in 65% of eyes with CNV due to angioid streaks, whereas visual acuity worsened in 35% of eyes.13

In our case, the patient had 22 intravitreal bevacizumab and 4 intravitreal aflibercept injections in the right eye and 3 intravitreal bevacizumab injections in the left eye after a 7-year follow-up period. The number of injections were determined based on the clinical and imagining findings of the patient. The patient did not visit the clinic for 10 months during the COVID-19 pandemic. This led to the progression of the subretinal membrane and a significant decrease in visual acuity in the left eye.

Thushanthi et al. showed in their case series, maximum follow-up of 10 years, anti-VEGF therapy is safe and effective in stabilizing and slowing progression of the disease. They started treatment with bevacizumab, then switched to ranibizumab or aflibercept in 66 eyes of 52 patients. Mean BCVA at baseline was 6/19 (62 ETDRS letters). At 2 years follow-up the mean BCVA was 6/15 (>5 ETDRS letters). After 5 or greater years of follow-up, there was average loss of ETDRS letters from baseline of 3.3 letters. Subfoveal CNV showed worse outcome in comparison with extrafoveal and juxtafoveal CNV.6

Similarly, in our case, the BCVA in the right eye was 20/50 after two years of follow-up. After 3 years of follow-up the BCVA was 20/63, after 4 years it decreased to 20/200. After 5 or greater years of follow up, the BCVA decreased to 20/400 and stayed stable.

The frequency of anti-VEGF treatment remains unclear. Some studies demonstrated that the frequent use of anti-VEGF agents in patients with angioid streaks may cause atrophic changes in the retinal pigment epithelium and neurosensory retinal layers because the breaks of the Bruch membrane allow the drug to easily enter the choriocapillaris.14 In our case after the initial loading dose the intravitreal bevacizumab injections were performed due to membrane activity, monitored by OCT images.

Conclusion

Rapid progression and high recurrence rates of CNV due to angioid streaks indicates poorer prognosis. Anti-VEGF therapy can help to stabilize the disease, however, a high rate of recurrence is inevitable. Long-term follow-up of the patient shows gradual vision worsening over time. Furthermore, there is a significant vision loss observed after 5-7 years of follow-up. One of the possible reasons for the worsening of the process in this case may be delayed visits to the clinic due to the COVID-19 pandemic.

Source of Funding

No source of funding.

Conflicts of Interest

No conflicts of interest.

References

1 

JA Shields JL Federman TL Tomer WH Annesley Angioid streaks. I. Ophthalmoscopic variations and diagnostic problemsBr J Ophthalmol197559525766

2 

FH Verhoeff Histological findings in a case of angioid streaksBr J Ophthalmol194832953144

3 

I Chatziralli G Saitakis E Dimitriou A Chatzirallis S Stoungioti G Theodossiadis ANGIOID STREAKS: A Comprehensive Review from Pathophysiology to TreatmentRetina2019391111

4 

I Georgalas D Papaconstantinou C Koutsandrea G Kalantzis D Karagiannis G Georgopoulos Angioid streaks, clinical course, complications, and current therapeutic managementTher Clin Risk Manag200951819

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M Gliem RP Finger R Fimmers CK Brinkmann FG Holz PC Issa Treatment of choroidal neovascularisation due to angioid streaks: a comprehensive reviewRetina2013337130014

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T Ramakrishnan S Chandra S Sivaprasad Long-term follow-up of management of choroidal neovascularisation secondary to angioid streaks with intravitreal anti-vascular endothelial growth factorEye20213538537

7 

K Tripathy JM Quint Angioid Streaks [Internet]StatPearls PublishingTreasure Island (FL)2022https://www.ncbi.nlm.nih.gov/books/NBK538151/

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JI Lim NM Bressler MJ Marsh SB Bressler Laser treatment of choroidal neovascularization in patients with angioid streaksAm J Ophthalmol1993116441423

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HE Grossniklaus WR Green Choroidal neovascularizationAm J Ophthalmol20041373496503

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Y Nakano K Kataoka J Takeuchi A Fujita H Kaneko H Shimizu Vascular maturity of type 1 and type 2 choroidal neovascularization evaluated by optical coherence tomography angiographyPLoS One2019144e0216304

11 

O Gal-Or C Balaratnasingam KB Freund Optical coherence tomography angiography findings of choroidal neovascularization in pseudoxanthoma elasticumInt J Retina Vitreous2015111

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M Battaglia Parodi P Lacono C Laspina L Berchicci F Scotti A Leys Intravitreal bevacizumab for nonsubfoveal choroidal neovascularization associated with angioid streaksAm J Ophthalmol20141573747

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C Alagöz N Alagöz A Özkaya U Çelik MF Turan AT Yazici Intravitreal bevacizumab in the treatment of choroidal neovascular membrane due to angioid streaksRetina20153510200110

14 

RP Finger PC Issa P Schmitz-Valckenberg FG Holz HN Scholl Long-term effectiveness of intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks in pseudoxanthoma elasticumRetina201131126878



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Article type

Case Report


Article page

435-438


Authors Details

Aygun Aliyeva*, Gunay Rustambayova


Article History

Received : 15-07-2022

Accepted : 25-07-2022


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