Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the  Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfill our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free more...


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Singh: Correlation between one month post operative refractive status with pre operative calculated IOL power


Introduction

Cataract surgery underwent huge evolution over the years. Being one of the most common elective surgical procedures, cataract surgeries witnessed huge improvement with personalized biometric measurements. Cataract surgery in the present era is considered more of refractive procedure and patients expect to have a glass free life. A correct IOL power can minimize the residual refractive error after surgery. Axial length and keratometry finding contribute to the IOL power. One of the most stablised correlation is between axial length and residual refractive error.1 While an error of 1mm measurement error causes 2.8 D calculation error of post refractive error and error of 1 D keratometry causes approximately error of approximate 1 D calculation error.2 Due to these reason ophthalmologist are extra careful in hyperopic eyes biometry and eyes with unusual findings. Formula related errors can cause errors of calculation. While srk/t is good for medium range eyes, hoffer q and haigis are good for extreme values.3 A scan, keratometry and formula errors all are included in IOL power. So it become interesting to see how different IOL power of the IOL number ranges gives residual refractive error. Spherical equivalent in ocular refraction is the power of external lens which is required to focus images clearly on retina.4 This study proposes to study the correlation between the value of IOL power and spherical equivalent of the refractive error after 4 weeks of temporal phacoemulsification.

Material and Methods

The study design was retrospective analysis which included 100 post-operative cataract patient data from month of January to June 2020 at Sankara eye hospital, Kanpur who underwent temporal phacoemulsification surgery. The surgeries were done by four different surgeon of equal competence. A scan was done by US biometry and IOL master. Automated k1, k2 readings were used The machine used for surgery was Alcon’s Laureate Foldable lenses from different brands were used in the surgery.

Inclusion criteria

  1. Cases in which temporal phaco were done.

  2. Senile cataract..

  3. Only those cases were selected in which final best corrected vision was 6/6 with or without correction..

  4. Patients whose 1 month post op data was available.

Exclusion criteria

  1. All complicated cataracts.

  2. Patients with ocular pathology.

  3. Patient with intraoperative and post op complication.

  4. Cases with history of any previous ocular surgery.

Preop evaluation was done and formula used were SRK/T., HOFFER Q AND HAIGIS.

Post op subjective refraction was done at 4 weeks and the subjective refractive error was converted into spherical equivalent. For every IOL used spherical equivalent was calculated at 4 weeks.

Post op treatment included E/d prednisolone acetate 1 drop 6 times taper weekly and E/d moxifloxacin 1 drop qid for 2 weeks.

Result

A total of 100 eyes were included in the study. The IOL power used were from range of -2.5 to 37 dioptre. Mean IOL power was 20.39 SD ±4.91. Mean axial length was 23.43 1.53.

The mean post op spherical equivalent refractive error was -0.32 SD ± 0.74 Among the total 84 percent eyes was within ±1.00D error. 23 patient was emmetropic, 53 patient were having myopic refractive error and 24 with hyperopic error. 16 patient had refractive error of >1.D. 13 percent patient had myopia more than 1D and 3 percent patient had hyperopia more than 1D. A total of 37 percent had spherical equivalent less than or equal 0.25(0-.25).57 percent patient had refractive error of less than or equal to 0.50. 72 percent patient had refractive error upto 0.75 D. 84 percent patient had refractive error upto 1 D. t Test were applied and the pearson correlation value between the IOL power and post op spherical equivalent error was -.097. Thus there was a no correlation between calculated pre op IOL power and post op spherical equivalent significant as p value came as 0.34.(r = -0.097, p= 0.34) Correlation between axial length and refractive error were negligible but not statistically significant in as in our study as p value is 0.34 which is more than 0.05. (r =0.096, p = 0.34).

.

Figure 1
https://typeset-prod-media-server.s3.amazonaws.com/article_uploads/d59ac383-d40d-4166-97e6-480c03460e20/image/eba1ffb9-49cf-49a2-959b-ddc304c7ffb1-uimage.png

Table 1

Refractive error

No. of patients

0

23

>0 ≤0.25   

14

>0.25- ≤0.5   

20

>0.5- ≤   0.75

15

>0.75- ≤1   

12

>1

16

Table 2

Mean

20.39

-0.32257

Variance

24.12919192

0.551330389

Observations

100

100

Pearson Correlation

-0.096984145

Hypothesized mean Difference

0

df

99

T Stat

41.1073811

P(T<=t) One - tail

2.48908E-64

t Critical one - tail

1.660391156

P(T=t)Two - tail

4.97817E-64

t Critical two - tail

1.984216952

Figure 2

Correlation of IOL power and refractive error (spherical equivalent)

https://typeset-prod-media-server.s3.amazonaws.com/article_uploads/d59ac383-d40d-4166-97e6-480c03460e20/image/69c6f253-02cc-43af-a891-0b5a9dc8a250-uimage.png

Discussion

All patient were evaluated for the spherical equivalent for refractive error at 4 weeks after best accepted subjective refraction was taken into account. Patients having myopic error or hyperopic error upto 1D are 84 percent. Correlation between IOL power and post op refractive error was not statistically significant in our study

This is consistent with Yunus Karabela et al.5 study that concluded that there was no correlation between IOL power and refractive error. In their study only axial length of 22.0-24.60 was included while in our study axial length from 19.0 to 30.05 mm was included. However a negative correlation between axial length and refractive error was found. Extreme value or unusual eye axial length were excluded. For the error >1.0 D in their study 4.25% were more hyperopic and more myopic than 1 D were 1.86%. In our study outside 1D range 13 percent were myopic out of the total. In their study 92.75% eyes refractive error was in range of 1D.

Our study result were similar with Aristodemou et al6 in which refractive error of less than 1 D were present in 80 percent of cases. Advantage of this study was a large sample size and values were taken from many surgical centres.

Hoffer et al7 study showed 94.5 percent patient were within range of 1.00D.

Olsen et al8 reported that 87 percent patient refractive error was within 1D limit. This study was similar to our study because it used different IOL type of different company and different formula were used. The IOL used were from range of 18.92 -37.45.

Correa et al9 studied retrospectively in 81 patient with axial length of 22-25mm and presented residual refractive error 40.7% within 0.50 D,35.7% within 0.51 to 1.25 D, 9.8% within 1.26 to 2D

Lagrasa et al10 reported 24% patients within 0.25 D, 55 percent within 0.5 D and 91 percent within 1D.

Bhatt et al11 reported that 18.8% of eyes were within 0.25D error, 37.5% of eyes were within 1.0 D refractive error and 71.3% of eyes were within 1.00D error.

In Hubaille et al12 study different types of foldable lenses of different brands were use as in our study. This study was also retrospective. They found the error were within 0.75 D in 78% cases and within 1 D in 88% cases.

Rajan et al.13 conducted study a range of axial length 23.4±1.2. Mean absolute error was .62 ±.40. 87 percent patient were within 1.00 D.

The royal college of ophthalmologist recommends the need to achieve post op target refraction of 1 D to be achieved in 90 percent of cases.

Although our study showed the in 84 percent cases refractive error was less than 1D Advantage of our study was all ranges of IOL numbers starting from a value of -2.5 D to 37 D were included and axial length from 19.0 to 30.5 mm were included that makes our data more inclusive and different formula as well as different lens type were used.

Disadvantage of our study is its small sample size, four different surgeon doing biometry and surgery.

There are various reasons of refractive surprise in surgery14

  1. Wrong biometry

  2. Preoperative corneal astigmatism

  3. Previous surgery like PKP

  4. Wrong formula used for calculation of IOL

  5. Astigmatism caused due to surgery

  6. Position of capsulorrhexis

  7. Post op anterior movement of IOL due to fibrosis.

There can be various method to reduce refractive surprise3

  1. Preoperative corneal astigmatism can be taken into account by taking incision on steeper axis.

  2. Patient who underwent sequential surgery the previous data should be taken into account during second surgery.

Conclusion

Our study with its result showed that there was no statistically significant correlation between IOL power and post op refractive error and so there is no way that we can guess about the residual refractive error on the basis of IOL power.

Source of Funding

None.

Conflict of Interest

The authors declare no conflict of interest.

References

1 

H Hashemi M Khabazkhoob M H Emamian M Shariati M Miraftab A Yekta Association between Refractive Errors and Ocular Biometry in Iranian AdultsJ Ophthalmic Vis Res20151032142010.4103/2008-322X.170340

2 

N Astbury B Ramamurthy How to avoid mistakes in biometryCommunity Eye Health20061960701

3 

DR Sanders JA Retzlaff MC Kraff HV Gimbel MG Raanan Comparison of the SRK/T formula and other theoretical and regression formulasJ Cataract Refract Surg19901633416

4 

F Chen P Duggal BE Klein KE Lee B Truitt R Klein Variation in PTCHD2, CRISP3, NAP1L4, FSCB, and AP3B2 associated with spherical equivalentMol Vis20162278396

5 

Y Karabela M Eliacik MS Kocabora SK Erdur H Baybora Predicting the refractive outcome and accuracy of IOL power calculation after phacoemulsification using the SRK/T formula with ultrasound biometry in medium axial lengthsClin Ophthalmol20171111439

6 

P Aristodemou NEK Cartwright JM Sparrow RL Johnston Formula choice: Hoffer Q, Holladay 1, or SRK/T and refractive outcomes in 8108 eyes after cataract surgery with biometry by partial coherence interferometryJ Cataract Refract Surg20113716371

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KJ Hoffer The Hoffer Q formula: a comparison of theoretic and regression formulasJ Cataract Refract Surg19931967001210.1016/s0886-3350(13)80338-0

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T Olsen H Gimbel Phacoemulsification, capsulorhexis, and intraocular lens power prediction accuracyJ Cataract Refract Surg19931966959

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ZMS Corrêa FL Kronbauer R Goldhardt IM Marcon F Bakowicz Precisão ecobiométrica da fórmula SRK/T na facoemulsificaçãoArq Bras Oftalmol20016432337

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JM Lagrasta N Allemann L Scapucin CT Moeller LE Ohkawara LA Melo Clinical results in phacoemulsification using the SRK/T formulaArq Bras Oftalmol200972218993

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AB Bhatt AC Schefler WJ Feuer SH Yoo TG Murray Comparison of predictions made by the intraocular lens master and ultrasound biometryArch Ophthalmol2008126792933

12 

C Hubaille V De Groot MJ Tassignon Comparison of preoperative target ametropia and postoperative refraction for three types of lenses and intra-ocular differences (one pliable acrylic, one pliable PMMA-copolymer and one non-pliable PMMA)Bull Soc Belge Ophtalmol20012803542

13 

MS Rajan I Keilhorn JA Bell Partial coherence laser interferometry vs conventional ultrasound biometry in intraocular lens power calculations Eye (Lond)2002165552610.1038/sj.eye.6700157

14 

JS Ladi Prevention and correction of residual refractive errors after cataract surgeryJ Clin Ophthalmol Res201754550



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© This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Article type

Original Article


Article page

492-495


Authors Details

Sneha Singh*


Article History

Received : 26-05-2021

Accepted : 26-05-2021

Available online : 30-09-2021


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