Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the  Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfill our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free more...


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Manikala: Treatment with Nd:YAG for posterior capsular opacification after cataract surgery


Introduction

One of the most common causes of blindness is cataract. The only way to cure this is by cataract surgery, with very good visual outcomes.1 A few complications may occur due to the surgery, there can be posterior capsular tear, detachment of Descemet’s membrane or even vitreous loss. Another most common complication is posterior capsule opacification (PCO), all of which can also lead to visual loss.2 PCO is due to the continuous growth of the lenticular epithelial cells which were left in the anterior capsule during the cataract surgery.3, 4 These cells multiply and form monolayers on the surface of the capsule and continue to do so for many years also after the surgery. This differentiation of the cells result in a structure called the Soemmerring’s ring and a thickened peripheral capsular bag. Near the capsulorhexis, swelling of the cells occur and result in globular Elschnig’s pearls, occluding the vision. The development of PCO may be due to various reasons such as lens material and the design of the implanted intraocular lens.3, 5, 6

The time taken for the opacification to occur may vary from months to a few years in adults. By 2 years, in the younger age groups, 100% of the opacification occurs. As the age group decreases, the rate of opacification also declines. The incidence in adults is reported to be 20.7% after 2 years of surgery and 28.5% after 5 years.7 Uveitis is the most common cause of PCO.8, 9 In India, 50-80% of the bilaterally blind persons is due to cataract.10

Currently, Neodymium Yttrium Aluminium-Garnet (Nd:YAG) is used for the treatment of posterior capsular opacification with very good results. This method was for the first time presented by Aron-Rosa and Fankhauser in 1980s.11, 12 Nd:YAG uses a quick pulsed laser, which is applied to a series of focal ablation in the posterior capsule, thereby creating a small opening in the visual axis. 11 The improvement in glare and contrast sensitivity has been reported after treatment with Nd:YAG in many patients.13, 14 This results in photodisruption and thereby clears the vision.13

Nd:YAG is a procedure that is very simple and can be done within 5 minutes. It does not need hospitalization of the patient and can be done in the outpatient ward itself. Immediately after the procedure, the patient is free to go home. Many times, an improvement in visual acuity is seen before his departure itself.

Like in every treatment, a few complications rarely occur due to Nd:YAG treatment, such as increase in the Intra ocular pressure, a risk of retinal detachment, oedema, endophthalmitis, vitreous prolapse.15, 16, 17

This study was done to analyse the improvement of visual acuity after PCO and also to estimate the total laser energy required to perform PCO.

Materials and Methods

129 eyes of 129 patients were included in this prospective study performed by the Department of Ophthalmology of Mallareddy institute of medical sciences and hospital, Telangana during a period of two years six months from March 2017 to September 2019. This study was cleared by the Institutional Ethical Committee and informed consent was obtained from all the patients after explaining the nature of the study in detail. 129 patients between the ages of 35 to 85 years, who were included in the study, had a successful cataract surgery and complained of failing vision after a period of time of the surgery. Those who did not regain their visual acuity after the surgery and those who had other pathology affecting vision such as corneal opacity or glaucomas were excluded from the study. Those unwilling to provide consent for the study were also excluded. All patients who were unwilling to come for follow up and those who didnot come for followup were also excluded from the study.

Once these patients were diagnosed having posterior capsular opacification, demographic details were collected from them. A thorough clinical examination was done. Complete ophthalmic history of the patient was taken. Visual acuity was done with Snellen’s chart. Intraocular pressure was measured by using applanation tonometry. Fundus examination, refraction of the eyes and slit lamp examination was also done for all the patients. The PCO was graded. 1 hour before the capsulotomy, 1 drop of 0.5% timolol was added to the affected eye. Dilation of the pupil was done using 1% topical tropicamide and 10% phenylephrine. The eye was anaesthesised using 4% lignocaine just before the procedure.

The procedure and the method was explained to the patient, the equipment was gently introduced. The head was rested on the chin rest in front of the laser and the straps were tightened. Using the slit lamp, the laser beam was focused on to the capsule and energy shots of 0.8mJ were given in a single pulse mode. This energy was increased as required. The pulses were given as close to the visual axis as possible. As infrared rays were produced by the Nd:YAG, an orange-red HE-Ne beam helped to focus the beam on the posterior capsule. The openings were made at 12 o’clock position and progressed towards the 6 o’clock position.

Post laser medication 0.5% timolol 1 drop 2 times per day

Results

Of the 129 patients in the study, 51(39.5%) were females and 78(60.5%) were males (Figure 1).

Figure 1

Distribution of patients based on gender

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/e54dd6a2-f3d3-4813-9fc8-f71009cdac0fimage1.png

The predominant age group that was affected was 51-65 years with 55.8% of the cases. The age group between 51-55 has 24 (18.6%) of the cases, 56-60 years had 22 (17.1%), 61-65 years had 26 (20.2%) of the cases, 66-70 and 71-75 years age group had 16 (12.4%) of the patients each (Fig: 1).

Figure 2

Distribution of patients based on age

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/e54dd6a2-f3d3-4813-9fc8-f71009cdac0fimage2.png

Predominant number of patients had opacification between 6-12 months (31.8). 38 people had between 13-18 months, while 26 patients had in between 19-24 months. 12 patients had PCO before 6 months interval after the cataract surgery. Most of these people were below the age of 50 years (Table 1).

Table 1

Time taken for opacification

Time interval between surgery and formation of opacifications

Number

Percentage

< 6 months

12

9.3%

6-12 months

41

31.8%

13-18 months

38

29.5%

19-24 months

26

20.2%

25-36 months

8

6.2%

>3years

4

3.1%

Most of the patients had either moderate or severe type of PCO. 77 (59.7%) of the patients had a visual acuity of 6/18-6/24 prior to the PCO laser treatment and 46 (35.7%) had 6/36-6/60, a severe kind of PCO. After the laser treatment, only 2 patients showed not much improvement, while most of the patients showed a marked improvement of a visual acuity of 6/12 -6/6, 6/24- 6/18 in 88 (68.2%) of the patients, while 39 (30.2%) showed 6/12 -6/6, 6/24- 6/18 visual acuity (Table 2).

Table 2

Grading of PCO and Pre and post laser visual acuity of the patients

Grade

Pre laser acuity

Post laser acuity

6/6 – 6/12 (Mild)

6 (4.7%)

88 (68.2%)

6/18 – 6/24 (Moderate)

77 (59.7%)

39 (30.2%)

6/36 – 6/60 Severe)

46 (35.7%)

2 (1.6%)

Amongst the patients, the best corrected visual acuity was 6/9 in 67 (51.9%) of the patients, and 6/18 in 27.9% of the cases. 21 (16.3%) of the patients had a perfect visual acuity of 6/6 and none of them has a poor visual acuity of 6/60 (Table 3).

Table 3

Post laser BCVA

BCVA

Number

Percentage

6/6

21

16.3%

6/9

67

51.9%

6/18

36

27.9%

6/24

3

2.3%

6/36

2

1.6%

6/60

0

0

Of the complications seen among the patients after the surgery, the most common was elevated intraocular pressure seen in 28 (21.7%) of the patients. 9 (7%) found glare while seeing and 3 (2.3%) had pitting over the IOL (Table 4)

Table 4

Complications of Nd:YAG capsulotomy

Complications

Number

Percentage

Intraocular pressure

28

21.7%

Glare

9

7%

Pitting over IOL

3

2.3%

Vitreous floaters

1

0.8%

Post laser iritis

4

3.1%

Discussion

One of the major complications following a cataract surgery is posterior capsular opacification. This can occur in surgeries with or without the intraocular lens implantation. Nd:YAG is a preferred mode of treatment as it is noninvasive.13

In the present study, 60.5% were males and 39.5% were females. In a study by Bari, 57% were males and 43% females, which corroborated our study.18 In other studies by Hasan et al. and Tayyab et al. also, the males were predominantly affected than the females.19, 20 In contrast, a study by Baratz et al. reported a higher incidence of women rather than men.21

More than half of the patients were between 51-65 years of age. The average age of the patients in a study by Soujanya et al. was 57 years.22 It was observed that the rate of opacification reduced with an increase in age. This was reported in a study by Emery et al. where the average age was 55 years while Westling et al. and Calissendorff et al. found no relation between opacification and age. 23, 24

In our study, we did not categorize PCO based on its types, however, Elschnig pearl type of PCO was found predominantly in a study by Soujanya et al, followed by fibrous type. 22

31.8% of the patients had opacification within 6-12 months of the cataract surgery, while 29.5% of them got it between 13-18 months. A longer duration was observed in a study by Bari of an average of 23 months. Another study by Kundi and Younus also reported a mean duration of 24 months.25 A mean of 2.4 years was observed in a study by Hasan et al.19 Emery et al. found the most common duration of 3-5 years to have PCO in their study.23

There was a marked improvement on the visual acuity among the patients after undergoing the Nd:YAG procedure Similar results were observed by Bari and Hasan et al. in their respective studies.18, 19

Pre laser, the Grade of opacification was 6/18-6/24 in 59.7% patients and 35.7% in 6/36-6/60 (severe PCO). It was successfully corrected to 6/6-6/12 in 68.2% of the cases, and 6/18-6/24 in 30.2% of the cases. Those who had a visual acuity of 6/12 before the laser treatment was corrected to 6/6 in all the patients. A study by Soujanya et al 90.9% of the patients had an improved acuity of >6/18 in their patients.22 Similar results were seen in the study by Patil et al, where post laser, 67% of the patients had a visual acuity of 6/9 or more. 30% of them had a visual acuity of 6/24.26 In their study, only 37% of the patients had very less improvement of visual acuity, which was in accordance to our study, where we had 2 (1.6%) of very little improvement. This less improvement was probably due to the thick PCO and underlying pathology.26 In the present study, there was an improvement of at least one Snellen’s line. Another study by Steinert et al. also showed a 87.8% who had an improved vision.27 Similar results were reported in a study by Erisa et al.28 In another study by Awan et al., 96% of non diabetic patients showed improvement in visual acuity after the procedure and in diabetic patients, improvement was seen in 92%.29

Of the complications seen in our study, the most common one was increase in the intraocular pressure, followed by complaint of glare by the patients. IOL pitting was observed in 2.3% of the cases. In the study by Patil et al., increase IOP was the most common complication, however, this was followed by IOL pitting seen in 7% of the cases.26 IOL Iritis was observed in 3.1% of the cases in our study, which was similar to the study by Patil et al. who observed iritis in 2% of the patients.26 In a study by Kaetes et al., iritis was found in 0.4% and vitritis in 0.7% after 6 months of operative period.30 Persistent uveitis was seen in 1.4% of the patients after a follow up of 7 months in a study by Chambless et al.31

Conclusion

Nd:YAG is found to be a very easy and non-invasive procedure to treat Posterior capsular opacification. It is found to be very effective and safe to perform. The complications associated with this procedure are also very minor and far less. Thus, the patients undergoing cataract surgery need to be monitored so that PCO can be detected early and treatment can be started at the earliest.

Source of Funding

None.

Conflict of Interest

The authors declare that there is no conflict of interest.

References

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© This is an open access article distributed under the terms of the Creative Commons Attribution License - Attribution 4.0 International (CC BY 4.0). which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Article type

Original Article


Article page

87-91


Authors Details

Sailaja Manikala


Article History

Received : 01-07-2020

Accepted : 11-07-2020

Available online : 30-03-2021


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