Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...

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Original Article


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441-446


Authors Details

Snigdha Sen, Himanshu K Yadav, Anu Jain, Ila Tripathi*, Yatendra Chahar, Rajendra Prakash Maurya


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Efficacy of topical autologous serum versus preservative free artificial tears in patients having isotretinoin induced dry eye diseases


Original Article

Author Details : Snigdha Sen, Himanshu K Yadav, Anu Jain, Ila Tripathi*, Yatendra Chahar, Rajendra Prakash Maurya

Volume : 10, Issue : 3, Year : 2024

Article Page : 441-446

https://doi.org/10.18231/j.ijceo.2024.076



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Abstract

Aims: Aim of this study was to compare the efficacy and safety of topical autologous serum versus preservative free artificial tears in management of systemic Isotretinoin induced dry eye
Materials and Methods: In this prospective observational analytical study a total of 182 eyes of 97 patients with systemic Isotretinoin induced dry eye were enrolled. Baseline evaluations including the ocular surface disease index (OSDI) scoring, Schirmer’s test, tear film break up time (TBUT) and National Eye Institute (NEI) grading for corneal and conjunctival staining were performrd. All study subject were underwent thorough ophthalmic examinations including best-corrected visual acuity (BCVA) assessments and intraocular pressure measurements. The study participants were divided into two groups: group I treated with 40% autologous serum (AS) and group II treated with preservative free artificial tears (PFAT). Follow-up evaluation were conducted at 15 days, 1 month, 2 months, and 3 months. Statistical Analysis: The results were analyzed using the Chi-square test and t-test. P<0> Result: After 3 months of treatment, a significant improvement was noticed in OSDI, Schirmer’s test, TBUT, and NEI Scoring in both AS and PFAT groups but improvement was found stronger in AS group as compared to PFAT group (p < 0> Topical autologous serum may be an effective alternative for treatment of dry eye condition caused by drug Isotretinoin.
 

Keywords: Acne vulgaris, Preservative free artificial tears, Autologous serum, Dry eye, Isotretinoin.


How to cite : Sen S, Yadav H K, Jain A, Tripathi I, Chahar Y, Maurya R P, Efficacy of topical autologous serum versus preservative free artificial tears in patients having isotretinoin induced dry eye diseases. Indian J Clin Exp Ophthalmol 2024;10(3):441-446

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