Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...

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Original Article


Article page

345- 350


Authors Details

Ramyash Singh Yadav, Chiranji Rai, Anzar Ahmed Ansari, Avinash Gupta*


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Effectiveness of intrastromal voriconazole injection in the management of deep non healing fungal corneal ulcer


Original Article

Author Details : Ramyash Singh Yadav, Chiranji Rai, Anzar Ahmed Ansari, Avinash Gupta*

Volume : 8, Issue : 3, Year : 2022

Article Page : 345-350

https://doi.org/10.18231/j.ijceo.2022.071



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Abstract

Introduction: One of the most difficult conditions to cure is often corneal fungus infections. Due to low stromal penetration, current topical antifungal medications are not very successful in the treatment of fungal keratitis, which makes it challenging to treat cases of deep fungal corneal ulcers.
Aims and Objective: To assess the efficiency of voriconazole intra stromal injection in the treatment of deep fungal corneal ulcers that donot heal.
Materials and Methods: In this prospective interventional study of thirty patients, deep non-healing fungal corneal ulcers were successfully treated by combining intrastromal voriconazole with topical therapy. Voriconazole 50 gm/0.1 ml was injected intrastromally into the corneas of 30 patients with deep stromal non-healing fungal corneal ulcers who had not responded to topical antifungal medication.
Results: Patients were monitored for six to ten weeks following the operation. The size of the corneal infiltration was noted to decrease more quickly, and in the majority of cases, ulcers completely disappeared between 6 to 10 weeks.
Conclusion: As an additional therapy, intrastromal voriconazole injection may be a safe and efficient strategy to treat cases of deeply seated fungal corneal ulcers that refuse to heal.
 

Keywords: Non- healing fungal corneal ulcer, Intrastromal injection, Voriconazole.


How to cite : Yadav R S, Rai C, Ansari A A, Gupta A, Effectiveness of intrastromal voriconazole injection in the management of deep non healing fungal corneal ulcer. Indian J Clin Exp Ophthalmol 2022;8(3):345-350

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