Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfill our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) of its content, which is likely to attract more readers and citations of articles more...


Article type

Original Article


Article page

699-702


Authors Details

Sunil Ganekal*, Syril Dorairaj, Varun Ganekal


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Effect of heparin sodium on postoperative inflammation after adult cataract surgery


Original Article

Author Details : Sunil Ganekal*, Syril Dorairaj, Varun Ganekal

Volume : 7, Issue : 4, Year : 2021

Article Page : 699-702

https://doi.org/10.18231/j.ijceo.2021.141



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Abstract

Aim: To evaluate the effect of use of ringer lactate solution supplemented with heparin sodium in patients undergoing cataract surgery.
Materials and Methods: In a prospective, double-blind, interventional study, 200 patients were included and were randomized to undergo cataract surgery using ringer lactate solution with or without 10 IU/ml heparin. All patients underwent phacoemulsification with hydrophobic acrylic foldable intraocular lens (IOL) implantation. The severity of anterior chamber inflammation and amount of pigment deposition of IOL was assessed by slit lamp biomicroscopy on day 1, 7, 28 and after 8 weeks postoperatively.
Results: Mean age in treatment and control group was 63.0± 11.5 years and 65.1±12.7 years respectively. A significant reduction in the severity of inflammatory cellular activity (p=0.001), flare (p=0.001) and pigment deposition on IOL (p=0.001) was noted on day 1 in the heparin treated group compared to the control group. However, no significant difference was observed in the amount of inflammatory activity as well as IOL pigment deposition beyond 1 week postoperatively. The inflammatory activity resolved almost completely in both the groups by the end of 8 weeks postoperatively.
Conclusion: Our study showed the beneficial effect of addition of heparin to irrigating solution during cataract surgery. Heparin treated eyes demonstrated a reduction in the early postoperative inflammation and IOL pigment deposition. The anti-inflammatory effect was observed in the early postoperative period.
 

Keywords: Cataract surgery, Heparin, Intraocular inflammation.


How to cite : Ganekal S, Dorairaj S, Ganekal V, Effect of heparin sodium on postoperative inflammation after adult cataract surgery. Indian J Clin Exp Ophthalmol 2021;7(4):699-702

Copyright © 2021 by author(s) and Indian J Clin Exp Ophthalmol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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